|
Welcome to visit the pages of the Koskinen Group. The Polytechnic School of Finland obtained the University status as the first Technically oriented University if the country in 1908, and 14 professorships were initially founded. Among them was one chair in chemistry, that of Organic Chemistry, which was held by Gustaf Komppa, who had a few years earlier managed to synthesize camphor in a landmark synthesis, which later has been considered as one of the pioneering syntheses of complex natural products, comparable to the syntheses of urea, glucose and terpineol.
Natural product synthesis has been the major theme of the Laboratory of Organic Chemistry in our institute ever since, as is obvious from the list of holders of the prestigious Komppa Chair. 1848-1874 Anders Olivier Saelan Recent publications:
Sauerland, S.J.K.; Castillo-Meléndez, J.A.; Nättinen, K.; Rissanen, K.; Koskinen, and A.M.P. ‘Enantioselective synthesis of homo-sphingosine derivatives from l-aspartic acid.’ Synthesis in press. ________________________________________________________________________________
Käsnänen, H.; Myllymäki, M.J.; Minkkilä, A.; Kataja, A.O.; Saario, S.M.; Nevalainen, T.; Koskinen, A.M.P.; Poso, A. ’ 3-Heterocycle-phenyl N-alkylcarbamates as FAAH inhibitors: Design, synthesis and 3D-QSAR studies.’ Chem.Med.Chem. in press. ________________________________________________________________________________
Pelšs, A.; Kumpulainen, E.T.T.; Koskinen, A.M.P. ‘Highly Chemoselective Copper Catalyzed Conjugate Reduction of Stereochemically Labile α,β-Unsaturated Amino Ketones.’ J. Org. Chem. 2009, 74, 7598-7601. ________________________________________________________________________________
Kallatsa, O.A.; Nissinen, M.; Koskinen, A.M.P. ‘Polyhydroxylated indolizidine alkaloids - synthesis of dideoxycastanospermine.’ Tetrahedron 2009, 65, 9285-9290. ________________________________________________________________________________
Habrant, D.; Stewart, A.J.W.; Koskinen, A.M.P. ‘Towards the total synthesis of Calyculin C: preparation of the C13-C25 spirocyclic core.’ Tetrahedron 2009, 65, 7927-7934. ________________________________________________________________________________
Kumpulainen, E.T.T.; Koskinen, A.M.P. ‘Catalytic Activity Dependency on Catalyst Components in Aerobic Copper-TEMPO Oxidation.’ Chem. Eur. J. 2009, 15, 10901-10911. ________________________________________________________________________________
Myllymäki, M.J.; Käsnänen, H.; Kataja, A.O.; Lahtela-Kakkonen, M.; Saario, S.M.; Poso, A.; Koskinen, A.M.P. ‘Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: insight into FAAH enantioselectivity by molecular docking and interaction fields.’ Eur. J. Med. Chem. 2009, 44, 4179-4191. ________________________________________________________________________________
Reux, B.; Nevalainen, T.; Koskinen, A.M.P. ’ Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2.’ Bioorg. Med. Chem. 2009, 17, 4441-4447. ________________________________________________________________________________
Minkkilä, A.; Myllymäki, M.; Saario, S.M.; Castillo-Melendez, J.A.; Koskinen, A.M.P.; Fowler, C.J.; Leppänen, J.; Nevalainen, T. ‘The Synthesis and Biological Evaluation of para-Substituted Phenolic N-Alkyl Carbamates as Endocannabinoid Hydrolyzing Enzyme Inhibitors.’ Eur. J. Med. Chem. 2009, 44, 2994-3008. ________________________________________________________________________________
Bassas, O.; Huuskonen, J.; Rissanen, K.; Koskinen, A.M.P. ’A Simple Organocatalytic Enantioselective Synthesis of Pregabalin.’ Eur. J. Org. Chem. 2009, 1340-1351. ________________________________________________________________________________
|
